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- New study may lead to therapeis for diabetic retinopathy
- Spop appears to boost bone development

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 Spop appears to boost bone development Alerter l'administrateur Recommander à un ami Lien de l'article 

New research may change our understanding of a specific protein's role in bone development. Its findings may lead to development of common bone diseases like osteoporosis. Osteoporosis, a bone disease that decreases bone strength, may lead to painful fractures. Men and women of all races have the chance to develop it. Fragile bones make people vulnerable to mild stresses or the force from a fall. Study from Penn State University offers a novel target for the diagnosis and intervention of skeletal diseases including osteoporosis. It finds that the Speckle-type POZ Protein (Spop) modulates skeletal development and the lack of the protein causes mice to have shorter digit bones and lower bone density. Spop has a role in Hedgehog signaling -- a signaling pathway that is crucial for the development and maintenance of organs. Scientists previously thought that the protein Spop turns down this signaling pathway. But the new study finds that the protein actually promotes Indian Hedgehog signaling. Indian Hedgehog is a protein that plays a critical role in bone development. The researchers removed the Spop gene in limbs of mice, and found that their limbs had less dense bone, and shorter fingers and toes. In the absence of Spop, a transcription factor called Gli3 was up-regulated, which decreased Hedgehog signaling. Furthermore, reducing the levels of Gli3 greatly rescued the skeletal defects caused by Spop deficiency. Collectively, the Spop protein is a positive regulator of Indian Hedgehog signaling and skeletal development. Osteoporosis involves reduced bone density, which increases the risk of fractures and fragile bones. Multiple methods such as X-Ray test, traditional radiography tests, and bone density test are being used in the diagnosis of osteoporosis. The new research may provides a new test to the condition. Current osteoporosis drugs may accompany side effects, including nausea, ulcer in stomach and irritable bowel syndrome. The growing geriatric population and increasing prevalence of osteoporosis stress the need to develop more effective drugs. CusAb provides Spop and Gli3 proteins and FITC conjugated antibody.

  Aucun commentaire | Ecrire un nouveau commentaire Posté le 11-12-2016 à 15h28

 New study may lead to therapeis for diabetic retinopathy Alerter l'administrateur Recommander à un ami Lien de l'article 

Retinopathy is a disease of the retina. Diabetic retinopathy is a diabetes complication. At first, diabetic retinopathy may cause no or only mild vision problems. But as time goes by, it can lead to blindness. Both type 1 or type 2 diabetes can lead to diabetic retinopathy. The longer an individual has diabetes, the higher the risk of diabetic retinopathy. Now, a study shows that a man-made version of soluble gp130 (sgp130) is very effective in preventing eye inflammation and retinal destruction in diabetes. The study is led by Augusta University. In diabetic retinopathy patients, circulating IL-6 in the blood and the fluid portion of the eyes is high. When circulating IL-6 increases, its receptor -- IL-6R -- also increases. Binding of IL-6 to the IL-6R induces homodimerization and recruitment of glycoprotein 130 (gp130), which leads to activation of downstream signaling. IL-6 signals via a receptor complex composed of the signal-transducing β-receptor gp130 and the non-signaling membrane-bound or soluble IL-6 receptor α (IL-6R, sIL-6R), which is referred to as classic and trans-signaling, respectively. IL-6, which is secreted by immune cells to stimulate immune response, has both pro- and anti-inflammatory effects. Accumulating evidence suggests that IL-6 is a major player in diabetic retinopathy. Augusta researchers previously found that inhibiting this IL-6 trans-signaling highly decreases the classic eye inflammation and the destruction that follows. For the new study, they tested whether sgp130-Fc can help to prevent inflammation in the eyes in diabetes. CusAb offers Recombinant EDNRB.

  Aucun commentaire | Ecrire un nouveau commentaire Posté le 04-01-2017 à 17h50

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  Blog créé le 09-12-2016 à 01h58 | Mis à jour le 04-01-2017 à 17h50 | Note : Pas de note